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Gallbladder-related events, including cholelithiasis and cholecystitis, occur more frequently with GLP-1 therapy, likely related to rapid weight loss rather than direct drug effects

2 Furthermore, GLP-1 RAs have been shown to modulate the hormonal milieu in PCOS

Encoded by the proglucagon (PG) gene, glucagon-like peptide-1 (GLP-1) 3 , which is secreted by intestinal L cells during the postprandial state, has been confirmed to play a significant role in glucose metabolism in multiple human and animal studies

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