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The standard version of many supplements, especially glutathione, is notorious for poor absorption
The widely cited "500 dalton rule" for skin penetration suggests molecules near or above that threshold struggle to cross intact stratum corneum, and hydrophilicity makes it worse
Properly controlled trials with structural and symptomatic outcome measures would establish whether BPC-157 provides disease-modifying effects or primarily symptomatic relief in joint disorders
Most healthcare providers recommend avoiding elective injectable glutathione during pregnancy and lactation given the lack of safety data
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