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The condition typically progresses through inflammatory, frozen, and thawing phases over 12 to 24 months
The 2025 NEJM trial comparing tirzepatide directly against semaglutide showed 20.2% versus 13.7% weight loss over the same treatment period
Semaglutide: Standard shelf life: 30-45 days refrigerated Maximum: 56 days (some clinical protocols allow) More stable than research peptides Pharmaceutical-grade formulations include additional stabilizers Tirzepatide: Standard shelf life: 30-45 days refrigerated Maximum: 56 days Similar stability to semaglutide Important note: Research chemical versions of semaglutide/tirzepatide may be less stable than pharmaceutical versions
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