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Furthermore, GCLC-KO mouse will serve as a useful tool to investigate the molecular mechanisms underlying neurodegeneration and in the development of new treatment strategies to address neurodegenerative diseases

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1 Division of Endocrinology, ASST Fatebenefratelli-Sacco, International Centre for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, Universit Degli Studi di Milano, Milan, Italy, 2 Division of Endocrinology, ASST Fatebenefratelli-Sacco, International Centre for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Sciences, Universit Degli Studi di Milano, Milan, Italy, 3 ASST Fatebenefratelli-Sacco, Milan, Italy, 4 ARIA S.p.A., Milan, Italy, 5 Division of Endocrinology, ASST Fatebenefratelli-Sacco, Milan, Italy, 6 IRCCS Ospedale Galeazzi - SantAmbrogio, International Centre for T1D, Universit Degli Studi di Milano, Milan, Italy, 7 ASST Fatebenefratelli-Sacco, Milan, Italy, 8 International Centre for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Sciences, Universit Degli Studi di Milano, Milan, Italy, 9 IRCCS MultiMedica Sesto San Giovanni, Milan, Italy, 10 Division of Endocrinology, ASST Fatebenefratelli-Sacco, International Centre for T1D, Pediatric Clinical Research Center Romeo ed Enrica Invernizzi, Department of Biomedical and Clinical Sciences, Nephrology Division, Boston Childrens Hospital, Milan, Italy

Besides reducing appetite and increasing calorie expenditure, Semaglutide GLP-1 improves insulin sensitivity, allowing better glucose uptake by cells and lowering blood sugar levels