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A useful comparison point is the acylation chemistry described for semaglutide by Lau and colleagues in the Journal of Medicinal Chemistry in 2015 [2], which introduced a C18 diacid linked through a spacer to achieve albumin binding on a GLP-1 scaffold
DSIP and the Opioid System One of DSIP's more unexpected research applications involves opioid withdrawal
10.1113/jphysiol.2005.086728 J
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