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Because metabolic regulation is distributed across multiple physiological systemsincluding endocrine tissues, liver, adipose tissue, and cardiovascular signaling pathways GLP-RTprovides a useful experimental tool for studying how coordinated receptor activation affects systemic metabolic biomarkers and physiological signaling responses
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Additionally, tirzepatide has been shown to restore cytokine-induced alpha cell impairment in a model of T1D [83]
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