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The glucagon component, in particular, helps explain why some patients respond differently to GLP-1 therapy, and why medications sometimes stop working
Our previous studies have indicated that microglial activation in the TNC contributes to the central sensitization of CM [17, 18]
The FDA has flagged safety risks for several compounded peptides, including immunogenicity and impurity concerns
A recent phase 2 trial testing doses of up to 16 mg/week suggests that, while higher doses yield further improvements in blood glucose and body weight, there is no clinical justification for exceeding the approved dose of 2 mg/week due to increased frequency of AEs
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