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JS is a 30-year-old right-handed male with a longstanding history of medically refractory epilepsy, initially diagnosed at age 14, and a more recent history of sTBI sustained after being struck by a motor vehicle while riding a scooter His epilepsy history includes generalized tonic-clonic seizures (GTCs), with the first documented seizure occurring in 2008, involving convulsive activity, drooling, unresponsiveness, and postictal confusion

Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers

The arginate form also offers advantages for systemic applications where the researcher wants broad distribution rather than localized effects