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This condition is often linked to lifestyle factors such as poor diet, obesity, and excessive alcohol consumption
The most frequent AEs included stomatitis and nausea (both 45%)
Active retinal vascular disease or other conditions sensitive to angiogenic signaling
1 As summarized in this review, resistance is not solely dictated by tumor-intrinsic genetic alterations but is shaped by a dynamic interplay among clonal evolution, signaling rewiring, epigenetic remodeling, altered DNA damage repair, metabolic adaptation, dysregulated cell death, TCP, microenvironmental remodeling, and hostmicrobetumor interactions
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