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In another experiment, the hesperidin flavonoid activated the secretion of superoxide dismutase and glutathione (Matias et al., 2017), rutin (Omar et al., 2017) can reduce the amount of free Ca 2+ located between brain cells when fighting against neurogenic excitotoxicity and can attenuate the decrease of the mitochondrial membrane potential and increase caspase-3 activity (Lutz et al., 2015)

As exogenous lipid resources are reduced, cells may initiate lipid catabolism to support the increasing lipid demand

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however, high doses of ALCA increased liver mitochondrial oxidant production [143]