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Cytidine deaminase and the development of resistance to arabinosyl cytosine

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Our findings demonstrated that A45, but not polyethylene glycol (PEG), elicited significant metabolic perturbations, particularly in amino acid, energy, and redox-related pathways, as well as connections to inflammation- and fibrosis-related phenotypes, consistent with its high fibrogenic potential

Because caspase-1 directly cleaves gasdermin D to drive pyroptosis, these results suggest that QVD does not fully block caspase-1 activity under these conditions