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The peptide backbone provides three coordination sites for copper: the free alpha-amino group of glycine, the deprotonated amide nitrogen of the glycyl-histidyl bond, and the imidazole nitrogen of the histidine side chain, with the lysine epsilon-amine remaining available for further interactions
If you do experience side effects, it is common for them to go away as your body adjusts to the medication
Ann Oncol 1997;8(6):569-573
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