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10.1074/jbc.M412898200 J
47,48 Moreover, active or inactive drug metabolites can influence both efficacy and adverse effects, as seen with prodrugs such as cyclophosphamide
Safety Across the seven PIONEER REAL studies, 1226 adverse events (AEs) in 551 participants (34.1%) were reported during the in-study observation period, and most of these were non-serious (1153 events in 528 participants) and mild or moderate in severity (Table 1)
This limit ensures the continued efficacy of the benzyl alcohol preservative and minimizes contamination risk
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