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Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine
G., Akolu, H
Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases
In POTS, this signaling fails, leading to blood pooling in the lower extremities and a rapid, compensatory spike in heart rate
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