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"This work not only highlights the potential off-target effect of semaglutide as an effective drug to treat metabolic osteoarthritis," the team from China and the US writes in their published paper, "but also reveals a weight loss-independent repair mechanism." In addition to mouse experiments, the researchers also conducted a randomized human trial to assess the effects of semaglutide on pain, mobility, and tissue degradation in individuals with osteoarthritis and obesity
They operate by influencing hormone systems associated with hunger, satiety, and energy utilization
[15] Liang Y, Xu X, Yin M, et al
Regulation of ERK1 and ERK2 by glucose and peptide hormones in pancreatic beta cells
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