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A., Ferrari, I., Gravina, A., Mereu, R., D'Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A
This combined effect facilitates A plaque buildup, contributing to AD pathogenesis ( Tau hyperphosphorylation: Chronic systemic inflammation and oxidative stress induced by gut microbiome dysbiosis activate tau kinases such as glycogen synthase kinase-3 beta (GSK-3) and cyclin-dependent kinase 5 (CDK5)
84 Chronic T-cell receptor (TCR) signaling and sustained antigen exposure contribute to CD8 T-cell senescence, functional paralysis, and eventual deletion, which are hallmarks of acquired resistance
A causative role of oxidative stress in ALD is supported by several lines of evidence 27
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