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The skin becomes visibly thinner, loses elasticity, and becomes prone to damage

In normal endometrial tissue, oestrogen may inhibit autophagy in the endometrium by inhibiting the hypoxia-inducible factor-1/ROS/AMP-activated protein kinase signalling pathway and further activating mammalian target of rapamycin complex (mTOR) signalling during nonmenstrual periods [100]

Tone starts to even out With twice-daily use, dullness softens and skin begins to look more uniform in the mirror and in photos