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Symptoms of Low Thyroid (Hypothyroidism) Reduced body temperature Cool skin Cold hands & feet Reduced appetite Weight gain Constipation Reduced muscle strength and stamina Puffiness of skin, especially in the face Depression Rapid hair loss Elevated cholesterol, and sometimes triglycerides Vitamin B12 deficiency, often due to autoimmune disease In women, ovaries become polycystic, which contributes to PCOS Did you notice the bullet point about cholesterol