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In one phase 2 study: Pancreatitis was reported in about 0.4% of participants (1 out of 267) Gallbladder issues affected roughly 1.1%, with no cases in the placebo group Heart rhythm changes were reported more often in people taking retatrutide (about 6% compared to 3% with placebo) Liver enzyme increases were rare (around 1%), and overall liver health markers stayed stable over time
doi: 10.1016/j.neuropharm.2009.03.011 59 GarbettK.EbertP
Some individuals experience initial detoxification responses as cellular glutathione elevation supports enhanced toxin mobilization and elimination
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