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Considering a three-dimensional structural model for a complex of the human HGF-NK2 segment sandwiched by c-met receptor molecules (see supplementary Figure 3, re-produced from PDB ID 7MO7 67 , it is hypothesized that the disulfide bonds, notably Cys149-Cys189 and Cys177-Cys201 localized internally just behind Y198, are the targets of LASSS
May be used in stepdown plans after IV phases
Generally, copper is able to exist in two oxidation states in the body of mammalians: Cu + and Cu 2+ (Lin and Kosman, 1990
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