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Pregnancy and breastfeeding : do not start glutathione or NAC supplements without medical advice, as evidence for routine supplementation in these groups is limited (despite medicinal use of NAC for paracetamol overdose under specialist supervision)
Some patients may experience mild side effects like nausea, diarrhea, or constipation, but these often subside
Central administration of the TLR4 inhibitor TAK242 enhanced leptin-induced suppression of food intake in rats with diet-induced obesity, but did not exert additive effects in RYGB-treated animals, indicating that RYGB may exert its benefits through this mechanism
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