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Its functional loss leads to a reprogramming of the metabolic network, promoting an abnormal increase in the metabolic flux from -KG to succinate
More recently it has been identified that mitochondria can be transferred between cells, which may be a mechanism for reducing cellular stress, either by enhancing energy production through supplementation of functional mitochondrial to a dysfunctional network or by removing defective organelles from cells with compromised quality control pathways (Shanmughapriya et al., 2020)
Tung C, Varzideh F, Farroni E, Mone P, Kansakar U, Jankauskas SS, et al
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