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To determine the solution structural model of the p53 TAD2 -FOXO4-DRI complex using NMR spectroscopy, we recorded several sets of NMR experiments on two types of complexes: 13 C, 15 N-labelled p53 TAD2 -FOXO4-DRI and 13 C, 15 N-labelled FOXO4-LRI D -p53 TAD2 (see methods)

Some people have genetic predisposition to carry fat in their arms, just like some women tend to carry weight in their hips more than their abdomen

A shift in cellular composition could masquerade as a pathway down-regulation

Both peptides maintain stability across the same pH range (4.0-8.0), so there are no compatibility concerns in the blended format