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However, there is still a significant difference between the WL that can be achieved with bariatric surgery and the currently approved obesity pharmacotherapies and there is heterogeneity in treatment responses with GLP-1 RA (for example people with T2D may achieve less WL compared to those without diabetes in clinical trials, despite similar lifestyle interventions) [13, 14]
Your body maintains a consistent appetite-suppression effect when injections occur on schedule, whereas skipping and then doubling up creates uneven drug exposure and unpredictable side effects like nausea or gastrointestinal distress
Regular monitoring through your GP with periodic liver function tests helps determine whether specialist referral is needed
These differences are usually small and dont meaningfully impact treatment
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