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Engineered exosomes that are surfacemodified with CD44 antibodies can specifically accumulate within inflamed joints, thereby augmenting the local concentration of methotrexate and substantially mitigating systemic side effects [456]

In particular, LEAP2 (liver-expressed antimicrobial peptide 2), an endogenous antagonist of the ghrelin receptor GHSR, has emerged as a potential target for mitigating the weight regain often observed after discontinuation of GLP-1-based therapies [22,23]

Expand therapeutic use By focusing on health optimization rather than disease treatment, microdosing opens up possibilities for a broader range of patients

Even in the trial, fibrosis improvement rates were more modest than MASH resolution