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Since the aim of this pre-planned study was to evaluate direct effects on biological systems induced by the treatment, a per-protocol approach (19) was deemed to more accurately provide an answer than the intention-to-treat approach to this aim

However, upon receipt, the product should be transferred immediately to appropriate cold storage

The higher 3.0 mg and 4.5 mg doses that were approved in 2020 demonstrated hemoglobin A1c reductions closer to 1.5% and slightly more weight loss

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