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28 In contrast, the BRONCUS study in which patients received a daily dose of 600 mg NAC showed no benefit in COPD, 29 whereas in the HIACE and PANTHEON studies in which the dose was 600 mg twice daily (BID), a decrease in the frequency of acute exacerbations was observed with NAC

Its overexpression can play a pro-oxidative role and induce ferroptosis by increasing Fe accumulation and lipid peroxidation [124, 125]

This combination supports better utilization of glutathione and aligns with how the body naturally processes antioxidants

Many protocols are time-based (for example, evening use to match circadian goals) and cycle-based (used for a defined period, then paused)