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A 2024 safety review in ScienceDirect noted that tirzepatide may have slightly better GI tolerability than semaglutide, likely because of its dual mechanism ( ScienceDirect , 2024)
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The FDAs primary enforcement mechanism is against vendors who make explicit health claims or market compounds as supplements or medicines
The approval builds on Uzedys 2023 indication for schizophrenia and data from Phase 3 RISE and SHINE trials confirming efficacy and tolerability
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