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If you have symptoms like fatigue, brain fog, or nerve pain plus suboptimal B12 levels, a trial of supplementation is worth trying since it's very safe

GHK-Cu is hydrophilic (water-loving), which limits its ability to penetrate the lipid-based skin barrier

Neuroinflammation induced by TNF- can affect the signaling of neurotrophins such as NGF and BDNF, which are essential for neuronal survival, growth, and plasticity (Saghazadeh and Rezaei 2017)