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Regions sharing a common letter do not differ significantly ( P Bonferroni-adjusted )
A retrospective study conducted at the University Health Network found that, in liver transplant recipients with diabetes, combination therapy reduced HbA1c and alanine aminotransferase levels more effectively than DPP-4 inhibitors. Additionally, two clinical trials in patients with Type 2 diabetes demonstrated that combination therapy significantly lowered HbA1c by 1.34% and 1.21%, compared to a 0.54% reduction with placebo, starting from a baseline of 8.0%. These findings suggest that combination therapy may be especially beneficial in the liver transplant population, where patients often experience weight gain and develop metabolic co-morbidities
The aforementioned studies suggest that SSRIs may contribute to the development of fetal myocardial injury, while also affecting maternal calcium homeostasis and steroid metabolism as well as inducing endocrine dysfunction, intrauterine fetal growth restriction, and neonatal maladaptation to the extrauterine environment (Figure 2)
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