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Cytoprotection as a common denominator
10.1111/j.1538-7836.2004.01085.x J Thromb Haemost
"When the vein is overworked from having to push blood up the body against gravity, the valves seals become leaky and blood is allowed to go backward, leading to the vein becoming enlarged." This explains why varicose veins almost always occur on the legs because when we're standing or sitting, our veins have to work against gravity to do their job
However, presumably to accommodate ()-catechin ( 12 ), the active site is substantially enlarged by a shift of the 4 and 4 helices by up to 1.71 (Fig
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