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doi: 10.1186/s13098-020-00603-6 352 YanFLiNShiJLiHYueYJiaoWet al
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10.1172/jci194745 J
Therefore, SGLT2-i diuretic properties show a major advantage compared to thiazides and thiazides-like diuretics, which act on the Na + CL - -cotransporter in the distal convoluted tubule, or loop diuretics, which block the Na-K-2Cl co-transporter of both the Henle loop and the macula densa, making the macula insensitive to the increased tubular sodium coming from the Henle loop
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