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That said, there are a few aging-related risks to understand before starting weight loss medications like Wegovy or Zepbound, including: Fall risk due to lost muscle mass Underdiagnosed hypoglycemia Nutritional deficiencies One of the biggest risks of GLP-1 agonist medications in the elderly population is loss of muscle mass because any weight loss will lead to loss of muscle mass, says Cynthia Odogwu, MD, a family and lifestyle medicine physician in Maryland