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Introduction# Ribupatide (HRS9531/KAI-9531, Hengrui Pharma/Kailera Therapeutics) and tirzepatide (Eli Lilly) share the same dual GLP-1/GIP receptor agonist mechanism, making this a direct mechanistic comparison
Complementing randomized trial evidence, extensive real-world observational data from large healthcare databases consistently demonstrate associations between GLP-1 receptor agonist utilization and decreased risks of MALOs involving cirrhosis, hepatic decompensation, HCC, and death from hepatic causes in patients with MASLD and type 2 diabetes
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