pyy and glp 1 Gut hormones like ghrelin (↑ hunger) & GLP-1/PYY (↓ hunger) signal to the hypothalamus' arcuate nucleus. Orexigenic (AgRP/NPY) & anorexigenic (POMC/CART) neurons integrate these signals, regulating… Graphical abstract. GLP-1: Glucagon-like peptide-1;
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