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Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Absent Core Comorbidities: Absent Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with skin involvement Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Present Core Comorbidities: Absent Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with core comorbidities Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Absent Core Comorbidities: Present Pediatric Generalized Joint Hypermobility [pGJH] Subtypes: Pediatric generalized joint hypermobility with core comorbidities and with skin involvement Musculoskeletal Complications: Absent Skin and Tissue Abnormalities: Present Core Comorbidities: Present Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, musculoskeletal subtype Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Absent Core Comorbidities: Absent Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, musculoskeletal subtype with skin involvement Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Present Core Comorbidities: Absent Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, systemic subtype Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Absent Core Comorbidities: Present Pediatric Generalized Hypermobility Spectrum Disorder [pgHSD] Subtypes: Pediatric generalized hypermobility spectrum disorder, systemic subtype with skin involvement Musculoskeletal Complications: Present Skin and Tissue Abnormalities: Present Core Comorbidities: Present Vascular EDS (vEDS) Genetic testing is used to see if a person has a genetic variant that causes vEDS

Epithelia are tight tissues due exclusively to the presence of TJ that selectively regulate the paracellular flux of ions (see Role of Tight Junctions in Crucial Physiological Processes)

& Kettenmann, H

Both compounds support mitochondrial function, and there is some evidence that supplementation may benefit individuals with primary mitochondrial diseases