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It has been suggested, based largely on work in animal models, that enduring changes in GABA A Rs expression induced by developmental exposure to steroid hormones, such as progesterone and its metabolites play a role in hippocampal neuronal excitability and in the etiology of sex-dependent neuropsychiatric disorders and memory deficits later in life (209211)
For endurance winter athletes training daily or multiple times per day, such sustained anti-inflammatory effects could meaningfully impact cumulative recovery and training capacity
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In vitro and animal-model studies have examined its interaction with angiogenic, nitric-oxide, and growth-factor signalling pathways relevant to soft-tissue research
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