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There are 14 million people in the United States whose BMI is over 40
Mechanism 2: DPP-4 inhibition
Direct oral anticoagulants (DOACs) such as apixaban, rivaroxaban, dabigatran, and edoxaban are substrates of P-glycoprotein (and some also of CYP3A4), so berberine could potentially increase their blood levels
They represent the formal regulatory position
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