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Pregnant or breastfeeding women, people with severe health conditions like chronic liver or kidney disease, and people with known allergies to any components of the injections should avoid them

The selectivity is documented in the foundational paper: a peer-reviewed European Journal of Endocrinology study demonstrating that Ipamorelin stimulates growth hormone selectively without elevating ACTH, cortisol, or prolactin, which is exactly why it has become the default selective secretagogue in modern peptide medicine

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Understanding why it happens can help people make more informed decisions about their medical treatments and seek out alternatives that may be less likely to trigger nausea