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Description

At the protein level, ROS can induce oxidation of amino acids, particularly cysteine and methionine residues

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Upon ingestion, N-Acetyl-L-Cysteine is rapidly deacetylated to L-Cysteine

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Tetrahydrobiopterin (BH 4 ) is an essential cofactor for eNOS required for efficient electron transfer during the synthases catalytic cycle ( 4 keeps eNOS in a coupled state, in which it synthesizes NO rather than harmful superoxide ( 4 can be produced through two pathways: de novo synthesis , regulated by the rate-limiting enzyme guanosine triphosphate cyclohydrolase I (GTPCH), or through the salvage pathway , where dihydrobiopterin (BH 2 ) is recycled back to BH 4 by dihydrofolate reductase (DHFR) ( 4 is rapidly oxidized into BH 2 by superoxide anions or peroxynitrite, which is particularly strong during NO scavenging (Milstien and Katusic, 1999)

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