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Hydration status significantly affects periorbital appearance with dehydration exaggerating dark circles through increased blood viscosity pooling more visibly, skin dullness from reduced cellular hydration making circles more prominent, and impaired lymphatic function allowing fluid retention despite overall dehydration
Research suggests that AOD-9604 peptide may have a targeted effect on areas of the body where fat accumulation is more common
"Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice." Biochemical Pharmacology
It is marketed as a food or dietary supplement, either alone, or in combination with vitamin C, alpha lipoic acid and other antioxidants
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