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Derosa et al., 2025)

Structurally, Retatrutide is derived from the glucagon peptide backbone and incorporates targeted amino acid substitutions that improve resistance to enzymatic degradation while maintaining receptor binding capability

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Monitoring during tirzepatide therapy should include regular assessment of gastrointestinal tolerability, as severe nausea and vomiting can lead to dehydration and electrolyte disturbances that may indirectly affect cardiovascular stability