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Our data demonstrate that the adaptive metabolic response to 5FU is mediated through the inhibition of TS function, as we recapitulate these phenotypes by genetic silencing or targeted inhibition of TS using antifolates
While oral supplements are convenient and accessible, they often have lower absorption rates than other forms, meaning that only a fraction reaches the liver
In simple terms, microdosing refers to using a fraction of a standard therapeutic dose , often around 1025% or less, taken regularly to see whether milder effects still provide benefit
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