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Pharmacological considerations should be discussed openly
Gastrointestinal symptoms (nausea, diarrhea, constipation, abdominal pain) are most common, typically occurring during dose escalation and often improving with continued use
ii) severe concurrent autoimmune diseases or active infections
The article described how the administration of an anti-mouse GIPR antibody (muGIPR-Ab) prevented weight gain in diet-induced obesity (DIO) mice, improved various metabolic parameters, and was associated with a reduction in food intake and the resting respiratory exchange ratio
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