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While there are a lot of people who microdose because of financial restraints, microdosing is also thought to have medical benefits, such as minimizing side effects
Overall, injections tend to produce the greatest average weight loss in clinical trials because they act on multiple hormone pathways
Baker, L
A 2025 systematic review and meta-analysis in Reviews in Endocrine and Metabolic Disorders found that tirzepatide (the active ingredient in Mounjaro and Zepbound) reduced hsCRP by approximately 33% and IL-6 by approximately 18% compared to placebo across patients with and without diabetes. A growing body of research suggests this effect occurs through direct action on the NF-B pathway, a master switch of inflammation
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