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Effective commercial life runs 5 to 12 years after approval
Most research supports 1 to 3 grams daily in divided doses taken with meals
Subcutaneous tumor-derived LOX was shown to increase vascular endothelial growth factor (VEGF) expression and secretion, which then promotes angiogenesis by phosphorylation of protein kinase B, or Akt, through platelet-derived growth factor receptor (PDGFRB)
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