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The receptors MC3R and MC4R are found primarily in the hypothalamus and are subjects of intense research in the fields of energy homeostasis and neuroendocrine signaling pathways

In terms of kidney function, while the initial eGFR for GLP-1 RAs users was notably lower, the difference was no longer significant by the D60-90 interval, hinting at a possible stabilization or amelioration in kidney function attributed to GLP-1 RAs therapy (Figure S2)

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