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Two individuals with PWS were found to have an abnormal ester-to-free carnitine ratio in addition to a low free carnitine level, plus elevations on acylcarnitine profiles, suggesting that there may be a small subset of the PWS population (approx 5%) who have a true secondary carnitine deficiency
Xia J, Yu J, Xu H, et al
The same mechanism plays a role in how the body feels hunger, which is why the drugs are valuable in weight loss
Typically, oral semaglutide is poorly absorbed because it is a protein-like molecule that the stomach naturally breaks down
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