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Retatrutide has 2.5-times lower potency at the GLP-1 receptor than human GLP-1, 8.9-times higher potency at the GIP-receptor than human GIP and 2.9-times lower potency at the GCG-receptor than human GCG [42]
Adjustments in diet and hydration often help mitigate these effects
Research shows GLP-1 medications like Ozempic (semaglutide) increase gastroparesis risk 3.67 times compared to alternative weight loss drugs, though most cases reverse after stopping the medication
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