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In the 1990s and 2000s, further non-RCT studies in the elderly with or without dementia/AD and low B12 status have also mostly shown no benefit of B12 for cognitive function
reported that among 146 patients with gastroparesis, nausea was present in 92%, vomiting in 84%, abdominal bloating in 75% and early satiety in 60% [25]
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According to FDA prescribing information and clinical trial data, nausea is the most common adverse effect, occurring in 15-44% of patients depending on the specific medication and dose
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